Scientific Research & Citations

Peer-reviewed studies on Intermittent Hypoxic-Hyperoxic Training (IHHT) and Hypoxia-Inducible Factors (HIF), the science behind cellular wellness.

Nobel Prize 2019

How Cells Sense and Adapt to Oxygen Availability

The 2019 Nobel Prize in Physiology or Medicine was awarded jointly to William G. Kaelin Jr., Sir Peter J. Ratcliffe, and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability through Hypoxia-Inducible Factors (HIF).

This foundational research established the molecular mechanisms that IHHT technology leverages for cellular adaptation and wellness benefits.

View Official Nobel Prize Citation

Peer-Reviewed Research

Published studies from PubMed-indexed journals demonstrating the science behind intermittent hypoxic training and cellular adaptation.

2020

Cellular Adaptation to Hypoxia Through Hypoxia-Inducible Factors and Beyond

Lee P, Chandel NS, Simon MC

Nature Reviews Molecular Cell Biology

PMID: 32144406
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2023

Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy

Mallet RT, Burtscher J, Richalet JP, Millet GP, Burtscher M

International Journal of Medical Sciences

PMID: 37859700DOI: 10.7150/ijms.86622
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2022

Influence of Acute and Chronic Intermittent Hypoxic-Hyperoxic Exposure Prior to Aerobic Exercise on Cardiovascular Risk Factors in Geriatric Patients

Behrendt T, Bielitzki R, Strobel P, et al.

Frontiers in Physiology

PMID: 36388103DOI: 10.3389/fphys.2022.1043536
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2022

Effects of Intermittent Hypoxia-Hyperoxia Exposure Prior to Aerobic Cycling Exercise on Physical and Cognitive Performance in Geriatric Patients

Behrendt T, Bielitzki R, Strobel P, et al.

Frontiers in Physiology

DOI: 10.3389/fphys.2022.899096
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2024

Adaptive Effects of Intermittent Hypoxia Training on Oxygen-Dependent Processes as a Potential Therapeutic Strategy Tool

Kurhaluk N, Lukash O, Nosar V, et al.

Cellular Physiology and Biochemistry

PMID: 38857359DOI: 10.33594/000000705
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2013

The Effects of Intermittent Hypoxia Training on Mitochondrial Oxygen Consumption in Rats Exposed to Skeletal Unloading

Kurhaluk N, Tkachenko H, Nosar V, et al.

Annals of Clinical & Laboratory Science

PMID: 23462606
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2023

Mechanisms Underlying the Health Benefits of Intermittent Hypoxia Conditioning

Serebrovskaya TV, Xi L

Journal of Physiology

PMID: 37860950
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Disclaimer: The research cited above represents published scientific literature on hypoxia science and intermittent hypoxic training. Mito2™ is a wellness technology device and is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.

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